Fusarium graminearum is a major fungal pathogen of cereals worldwide, causing seedling, stem base and floral diseases, including Fusarium Head Blight (FHB). In addition to yield and quality losses, FHB contaminates cereal grain with mycotoxins, including deoxynivalenol (DON), which are harmful to human, animal and ecosystem health. Currently, FHB control is only partially effective due to several intractable problems.
RNA interference (RNAi) is a natural mechanism that regulates gene expression. RNAi has been exploited in the development of new genomic tools, which allow the targeted silencing of genes of interest in many eukaryotes. Host-Induced Gene Silencing (HIGS) is a transgenic technology used to silence fungal genes in planta during attempted infection and thereby to reduce disease levels. Read more